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-alkoxycarbonyl indazole derivatives. The indazole synthesis can even be done making use of hydrazine dicarboxylates as reaction partners with the synthesis of indazoles, on the other hand, required a stoichiometric amount of copper(ii) acetate to the C–N bond formation phase.
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: Indazole-made up of derivatives represent one of The most crucial heterocycles in drug molecules. Diversely substituted indazole derivatives bear a range of useful groups and Screen flexible Organic actions; therefore, they have indazole drugs attained appreciable interest in the sphere of medicinal chemistry.
The indazole core is an interesting pharmacophore because of its purposes in medicinal chemistry. Up to now few years, this moiety continues to be employed for the synthesis of kinase inhibitors.
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Substrates 1b–d bearing methoxy and benzyloxy groups offered indazoles 4e–g in a great to reasonable generate. In the case of substrates 1e,f bearing electron-withdrawing substituents, yields of products 4h, i were being lowered.
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